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The movement and pathogenicity of trypanosomatid species, the causative agents of trypanosomiasis and leishmaniasis, are dependent on a flagellum that contains an axoneme of dynein-bound doublet microtubules (DMTs). In this work, we present cryo–electron ...
The flagellum of Trypanosoma brucei drives the parasite’s characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this process remain unclear. Here, we present high-...
Diet influences macronutrient availability to cells, and although mechanisms of sensing dietary glucose and amino acids are well characterized, less is known about sensing lipids. We defined a nutrient signaling mechanism involving fatty acid–binding ...
In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morphogenesis. How membrane-localized receptors and ligands ...
Some researchers worry about risks of devaluing sign language, overreliance on imperfect devices
Breach of Kakhovka Dam now threatens seasonal floods thick with toxic heavy metals, other pollutants
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Piezoelectricity is primarily observed in noncentrosymmetric insulators or wide bandgap semiconductors. We report the observation of the piezoelectric (PE) effect in half-Heusler (HH) narrow-bandgap semiconductors TiNiSn, ZrNiSn, and TiCoSb. These ...
The use of water as a weapon in highly industrialized areas in the Russo-Ukrainian war has resulted in catastrophic economic and environmental damages. We analyze environmental effects caused by the military destruction of the Kakhovka Dam. We link field,...
Current organic light-emitting diode (OLED) technology uses light-emitting molecules in a molecular host. We report green circularly polarized luminescence (CPL) in a chirally ordered supramolecular assembly, with 24% dissymmetry in a triazatruxene (TAT) ...
The ozonolytic deconstruction of aromatics remains a challenge in organic chemistry. Ozone preferentially reacts with alkenes over arenes, meaning that once the initial aromatic cleavage occurs, the dearomatized products are inherently more reactive than ...
Editors’ selections from the current scientific literature
Highlights from the Science family of journals
Our Research Article shows that evidence-based artificial intelligence (AI) dialogues reduce conspiracy beliefs much more than expected on the basis of previous work. Nabavi et al. agree with our conclusion that personalized conversations are crucial in addressing epistemically unfounded beliefs. However, they argue that this approach alone will not be enough to solve the misinformation challenge. Of course, we agree that no single solution, including AI chatbots, will address this challenge (1). We did not claim that AI dialogues alone could “save societies from misinformation and conspiracy theories” but rather that the strategy could serve as part of a toolkit to combat inaccurate beliefs.
In their Research Article “Durably reducing conspiracy beliefs through dialogues with AI” (13 September 2024, p. 1183), T. H. Costello et al. provide evidence that dialogue with generative artificial intelligence (AI) can reduce conspiracy beliefs. The paper’s conclusions frame AI as a potentially scalable intervention that can save societies from misinformation and conspiracy theories (1, 2). However, the applicability of this strategy to real-world problems remains unclear.
HomeScienceVol. 387, No. 6739Support PhDs building deep-tech venturesBack To Vol. 387, No. 6739 Full accessLetter Share on Support PhDs building deep-tech venturesTheo Diamandis, Josué J. López, and Fiona Murray [email protected]Authors Info & AffiliationsScience13 Mar 2025Vol 387, Issue 6739p. 1157 PREVIOUS ARTICLEScience at Sundance 2025PreviousNEXT ARTICLEThe problem with AI dialogue at scaleN…
Implications draw on the history of transformative information systems from the past
Membrane projections from muscle cells enable signaling in the developing mouse heart
A deep-learning model infers large-scale dynamics of Antarctic ice shelves
Rattan palms illuminate the drivers of biodiversity in tropical Asia
A lipid chaperone enables sensing of an essential fatty acid to drive tumor growth
HomeScienceVol. 387, No. 6739Science at Sundance 2025Back To Vol. 387, No. 6739 Full accessBooks et al.Review RoundUp Share on Science at Sundance 2025Valerie Thompson [email protected], Gabrielle Kardon [email protected], [...] , Michael D. Shapiro [email protected], Paul L. Koch [email protected], and Robert S. Krauss [email protected]+2 authors fewerAuthors Info & AffiliationsScience13 Mar 202…
A partnership can be demanding, and as with any couple, can have good days and bad. The United States–Canada relationship is most definitely having a bad one. It’s difficult to fully comprehend all the dimensions of the current threats to one of the ...
Expedition finds H5N1 in 13 bird and seal species on the Antarctic Peninsula
Ancient remains suggest at least two types of early humans roamed Europe about 1 million years ago
Fetal and infant brains offer clues to when human experience begins
A Science investigation finds no sign that members of a key CDC vaccine committee are compromised
In trio of studies, scientists explore life in the mysterious hadal zone
Science has identified more than two dozen halted grants amid Trump’s transgender crackdown, right as NIH suspends its own researchers who worked on topic
The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal antigens to CD4+ T cells and inducing their ...
Analysis suggests our planet’s oxygen levels rose surprisingly early
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork collisions with preformed G4s in the parental DNA ...
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution and lung repair during severe respiratory viral ...
Manioc—also called cassava and yuca—is among the world’s most important crops, originating in South America in the early Holocene. Domestication for its starchy roots involved a near-total shift from sexual to clonal propagation, and almost all manioc ...
Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion microscopy (RiboExM) to visualize individual ribosomes and ...
Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disruption results in lifelong metabolic consequences ...
Understanding the capacity of forests to adapt to climate change is of pivotal importance for conservation science, yet this is still widely unknown. This knowledge gap is particularly acute in high-biodiversity tropical forests. Here, we examined how ...
Tackling a touchy subject, genetic detective finds only 1% of European children have unexpected paternity
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Integrated optoelectronics has emerged as the backbone of information exchange across all scales of modern digital infrastructure—from on-chip interconnects and board-level optical links to chassis-to-rack communications and transcontinental data center ...
Global change drives biodiversity shifts worldwide, but these shifts are poorly understood in highly diverse tropical regions. In tropical mountains, plants are mostly expected to migrate upslope in response to warming. To assess this, we analyze shifts ...
Editors’ selections from the current scientific literature
Highlights from the Science family of journals
In November, representatives of Paris Agreement signatory countries will meet at the Conference of the Parties (COP30) in Brazil. Before the meeting, each country should strengthen its nationally determined contributions (NDCs) to reducing greenhouse gases by incorporating plastic emissions into its plans. Plastic production and waste contribute substantially to greenhouse gas emissions, yet 94% of Paris Agreement signatory countries (183 countries of 194 total) ignore plastics within their NDC plans, creating a major gap in climate mitigation efforts (1). Countries should compile their plastic-related emissions data (2) and use the information to amend NDC plans.
In their Research Article “A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors” (6 December 2024, p. 1128), T.-H. Lin et al. find that a mutation from glutamine to leucine at the 226 residue in the hemagglutinin protein of the H5N1 influenza virus leads to human receptor specificity, consistent with other work showing that the new H5N1 avian and bovine influenza virus variants exhibit altered receptor binding preferences (1, 2). Traditionally associated with avianspecific α-2,3–linked sialic acid receptors, emerging H5N1 strains display a growing ability to bind humanlike α-2,6–linked sialic acid receptors (3, 4), increasing the risk of human infection.
HomeScienceVol. 387, No. 6738Prepare now for a potential H5N1 pandemicBack To Vol. 387, No. 6738 Full accessLetter Share on Prepare now for a potential H5N1 pandemicJesse L. Goodman [email protected], Norman W. Baylor, [...] , Rebecca Katz, Lawrence O. Gostin, [...] , Rick A. Bright, Nicole Lurie, and Bruce G. Gellin+4 authors +2 authors fewerAuthors Info & AffiliationsScience6 Mar 2025Vol 387, I…
An AI safety specialist confronts fears about the future of large language models
Earth’s ancient flora comes to life in a vivid romp through 15 fossil sites
Evaluation guides strategy for the polio eradication endgame
Two-dimensional materials stabilize perovskites for charge transfer under heat and light irradiation
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