AAAS: Science Translational Medicine: Table of Contents
Science Translational Medicine: At the intersection of science, engineering and medicine.
Mutational inactivation of the pentameric complex does not prohibit congenital RhCMV transmission in a rhesus macaque model with seronegative dams.
An anti-CotH humanized IgG1 antibody protects against lethal mucormycosis when given as adjunctive therapy to immunocompromised mice.
A hydrogel providing sustained release of a JUN inhibitor reduces postoperative abdominal adhesion in murine and porcine models.
NRP2 is a target for resolving lung inflammation by a therapeutic histidyl-tRNA synthetase splice variant.
Neoadjuvant HIPEC improves ovarian cancer patient response, enabling hyperthermic immunotherapy based on cell heterogeneity. Neoadjuvant HIPEC improves ovarian cancer patient response, enabling hyperthermic immunotherapy based on cell heterogeneity.
The IRG1/itaconate pathway modulates microglial proinflammatory activation after traumatic brain injury in mice.
In extremely premature infants, immune cell trajectories are distinct from those of full-term infants over the first 60 days of life.
Engineered hyaline-like cartilage tissues are superior to immature cell-based grafts for the therapy of cartilage defects in the human knee.
Antibodies identified in the sera of norovirus vaccinees exhibit cross-neutralization across GII.4 variants or GII genotypes of human norovirus.
An oral norovirus vaccine tablet is safe and induces strong mucosal and systemic immune responses in adults aged 55 to 80 years.
Bispecific antibodies incorporating a cross-reactive NTD-specific antibody are resilient to SARS-CoV-2 variants of concern.
GOLPH3L suppressed STING-NLRP3–mediated pyroptosis, resulting in suppressive TIME, driving GBM resistance to RT.
TUDCA from gut E. lenta hinders AMPK activation and neutrophil phagocytosis, worsening bacterial lung infection in patients with bronchiectasis.
An AAV9 vector expressing both BCKDHA and BCKDHB rescues two murine models and a calf with classic maple syrup urine disease.
An electroadhesive hydrogel interface achieves 30-day gastrointestinal retention for prolonged porcine mucosal theranostics.
Early bone marrow transplant with busulfan preconditioning halts sickle cell–mediated arterial damage in a humanized mouse model.
NK cells and CD8+ TEMRA cells expressing NK receptors and disease-associated T cell receptors may drive autoimmunity in aplastic anemia.
Reduced cerebellar rhythm, driven by climbing fiber–to–Purkinje cell denervation, contributes to motor rhythm loss of cerebellar ataxia.
In the Research Article “BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure” by Q. Duan et al., Figs. 1G and 2G show the results of wheat germ agglutinin staining of mouse heart tissue histological sections to quantify myocyte cross-sectional area. The sham-vehicle controls and sham-JQ1 controls for this specific assay were performed using hearts from the same set of animals. The sham-JQ1 control images in Fig. 2G has been corrected, and the Fig. 2G caption has been revised to clarify the animals used. The other data and conclusions in the manuscript are not affected.
Mechanotransduction inhibition yields porcine and human skin wound regeneration by altering fibroblast subpopulation dynamics and immune cross-talk.
Glycoprotein GP38-specific antibodies reduce viral dissemination and GP38-mediated vascular leak in Crimean-Congo hemorrhagic fever virus infection.
The pentose phosphate pathway metabolite gluconolactone promotes regulatory T function to improve lupus symptoms in mice and humans.
β cell dedifferentiation underlies diabetes mellitus in Wolfram syndrome, and Txnip inhibition prevents β cell regression in Wfs1-deficient mice.
In patients with glioblastoma, navtemadlin resistance is not mediated by TP53-inactivating mutations, and combination with TMZ may improve efficacy.
Tumor-associated extrafollicular B cells are phenotypically, locationally, and functionally distinct from germinal center–dependent memory B cells.
MSH3 lowering by antisense oligonucleotides dose-dependently reduces CAG repeat expansions in iPSC-derived neurons from a patient with HD.
A high-throughput, noninvasive, rapid protease-activated nanosensor identifies patients with pancreatic cancer in a small volume of blood.
Intestinal epithelium–derived IL-34 regulates macrophage polarization in an apolipoprotein E–dependent manner and mitigates gastrointestinal GVHD.
PD-L1 from tumor extracellular vesicles induces T cell senescence through lipid metabolism.
Repair Drive enables in vivo expansion of gene-targeted hepatocytes in adult mice.
Activation of innate immune suppressive cells drives acquired resistance to Toll-like receptor agonism–based cancer immunotherapy.
Pseudomonas infection after lung transplantation induces acute intragraft lymphocytotoxicity that promotes antibody-mediated rejection in mice (Liao et al., this issue).
Both distinct and common cerebrospinal fluid proteomic signatures were observed in the different genetic forms of frontotemporal dementia.
S6 kinase 2 is a vulnerability in mitogen-activated protein kinase inhibitor–resistant NRAS-mutant melanoma.
P. aeruginosa causes antibody-mediated rejection in lung allografts that can be prevented by CXCR3 blockade in a mouse model.
Translocating pathobiont Enterococcus gallinarum promotes human TH17 and anti-RNA IgG3 autoantibody responses in patients with autoimmune disease.
Mathematical modeling of relapse data predicts tuberculosis drug regimens, identifying short, potential combinations for clinical trials.
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